Plasma Surface Functionalization

Plasma Surface Functionalization


Low pressure plasma is a universal tool for polymer surface functionalization and structuring. The group aims to provide a variety of plasma-based techniques including ‘simple’ plasma treatment, 'grafting to' and 'grafting from' plasma activated surfaces, plasma immobilization of pre-deposited molecules, adsorption of charged macromolecules on plasma activated surfaces as well as plasma polymerization. Research activities are focused on structured stimuli-responsive coatings for biomedical purposes and on the surface functionalization of 3D scaffold structures.

Fields of Research

  • Development of  thermo-responsive cell culture carriers including handling and transfer systems.  
  • Biomolecular functionalization of tissue engineering scaffolds made of poly(3-hydroxybutyrate).

Selected Publications

  1. Nitschke, M.; Ricciardi, S.; Gramm, S.; Zschoche, St.; Herklotz, M.; Rivolo, P.; Werner, C.
    Surface modification of cell culture carriers: Routes to anhydride functionalization of polystyrene more
    Colloids and Surfaces B: Biointerfaces 90 (2012) 41-47

  2. Salem, T.; Uhlmann, P.; Nitschke, M.; Calvimontes, A.; Hund, R.-D.; Simon, F.
    Modification of plasma pre-treated PET fabrics with poly-DADMAC and its surface activity towards acid dyes more
    Progress in Organic Coatings 72 (2011) 168-174

  3. Calvimontes, A.; Mauersberger, P.; Nitschke, M.; Dutschk, V.; Simon, F.
    Effects of oxygen plasma on cellulose surface more
    Cellulose 18 (2011) 803-809

  4. Roth, J.; Albrecht, V.; Nitschke, M.; Bellmann, C.; Simon, F.; Zschoche, St.; Michel, S.; Luhmann, C.; Voit, B.; Grundke, K.
    Tailoring the surface properties of silicone elastomers to improve adhesion of epoxy topcoat more
    Journal of Adhesion Science and Technology 25 (2011) 1-26

  5. Schröder, K.; Ohl, A.; Nitschke, M.
    Plasmaprozesse zur Beeinflussung der Biokompatibilität von Oberflächen more
    Eugen G. Leuze Verlag (2010) 1106-1124

  6. Lehmann, K.; Herklotz, M.; Espig, M.; Paumer, T.; Nitschke, M.; Werner, C.; Pompe, T.
    A new approach to biofunctionalisation and micropatterning of multi-well plates more
    Biomaterials 31 (2010) 8802-8809

  7. Cordeiro, A. L.; Zimmermann, R.; Gramm, S.; Nitschke, M.; Janke, A.; Schäfer, N.; Grundke, K.; Werner, C.
    Temperature dependent physicochemical properties of poly(N-isopropylacrylamide-co-N-(1-phenylethyl) acrylamide) thin films more
    Soft Matter 5 (2009) 1367-1377

  8. Cordeiro, A. L.; Nitschke, M.; Janke, A.; Helbig, R.; D'Souza, F.; Donnelly, G. T.; Willemsen, P. R.; Werner, C.
    Fluorination of poly(dimethylsiloxane) surfaces by low pressure CF4 plasma - physicochemical and antifouling properties more
    eXPRESS Polymer Letters 3 (2009) 70-83

  9. Cordeiro, A. L.; Zschoche, St.; Janke, A.; Nitschke, M.; Werner, C.
    Functionalization of poly(dimethylsiloxane) surfaces with maleic anhydride copolymer films more
    Langmuir 25 (2009) 1509-1517

  10. Roth, J.; Albrecht, V.; Nitschke, M.; Bellmann, C.; Simon, F.; Zschoche, St.; Michel, S.; Luhmann, C.; Grundke, K.; Voit, B.
    Surface functionalization of silicone rubber for permanent adhesion improvement more
    Langmuir 24 (2008) 12603-12611

  11. Nitschke, M.; Gramm, S.; Götze, T.; Valtink, M.; Drichel, J.; Voit, B.; Engelmann, U.; Werner, C.
    Thermo-responsive poly(NiPAAm-co-DEGMA) substrates for gentle harvest of human corneal endothelial cell sheets more
    Journal of Biomedical Materials Research 80A (2007) 1003-1010

  12. Pompe, T.; Mothes, M.; Mothes, G.; Nitschke, M.; Teese, M.; Zimmermann, R.; Werner, C.
    Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion more
    Biomaterials 28 (2007) 28-37

  13. Nitschke, M.; König, U.; Lappan, U.; Minko, S.; Simon, F.; Zschoche, St.; Werner, C.
    Low pressure plasma-based approaches to fluorocarbon polymer surface modification more
    Journal of Applied Polymer Science 103 (2007) 100-109

  14. Nitschke, M.; Uhlmann, P.; Schulze, R.; Werner, C.
    Plasma polymerization of tetrafluoroethylene - towards CF2 dominated fluorocarbon films more
    e-Polymers : no. 006 (2006) 10 Seiten

  15. Hahn, M.; Pleul, D.; Nitschke, M.; Frens, G.; Bundel, G.; Prause, S.; Simon,
    Plasma modification of diamond surfaces more
    Journal of Adhesion Science and Technology 19 (2005) 1039-1052

  16. Schmaljohann, D.; Beyerlein, D.; Nitschke, M.; Werner, G.
    Thermo-Reversible Swelling of Thin Hydrogel Films Immobilized by Low-Pressure Plasma more
    Langmuir 20 (2004) 10107-10114

  17. Bratskaya, S.; Marinin, D.; Nitschke, M.; Pleul, D.; Schwarz, S.; Simon, F.
    Polypropylene Surface Functionalization with Chitosan more
    Journal of Adhesion Science and Technology 18 (2004) 1173-1186

  18. Nitschke, M.; Zschoche, St.; Baier, A.; Simon, F.; Werner, C.
    Low pressure plasma immobilization of thin hydrogel films on polymer surfaces more
    Surface and Coatings Technology 185 (2004) 120-125

  19. Sabbatovskii, K.G.; Dutschk, V.; Nitschke, M.; Simon,; Grundke, K.
    Properties of the Teflon AF1601S Surface Treated with the Low-Pressure Argon Plasma more
    Colloid Journal 66 (2004) 208-215

  20. Schmaljohann, D.; Oswald, J.; Jörgensen, B.; Nitschke, M.; Beyerlein, D.; Werner, C.
    Thermo-Responsive Hydrogels for Controlled Cell Adhesion and Detachment more
    Polymeric Materials: Science and Engineering 89 (2003) 255-256

  21. Grundke, K.; Nitschke, M.; Minko, S.; Stamm, M.; Froeck, C.; Simon, F.; Uhlmann, St.; Pöschel, K.; Motornov, M.
    Merging Two Concepts: Ultrahydrophobic Polymer Surfaces and Switchable Wettability more
    VSP, Utrecht (2003) 267-291

  22. Minko, S.; Müller, M.; Motornov, M.; Nitschke, M.; Grundke, K.; Stamm, M.
    Two-level Structured Self-Adaptive Surfaces with Reversibly Tunable Properties more
    Journal of the American Chemical Society 125 (2003) 3896-3900

  23. Vasilets, V.N.; Simon, F.; Werner, C.; Hermel, G.; Pleul, D.; Nitschke, M.; Menning, A.; Janke, A.; Jacobasch, H.-J.
    Plasma assisted immobilization of poly(ethylene oxide) onto fluorocarbon surfaces more
    Journal of Adhesion Science and Technology 16 (2002) 1855-1868

  24. König, U.; Nitschke, M.; Pilz, M.; Simon,; Arnhold, Ch.; Werner, C.
    Stability and Ageing of Plasma Treated Poly(tetrafluoroethylene) Surfaces more
    Colloids and Surfaces B: Biointerfaces 25 (2002) 313-324

  25. König, U.; Nitschke, M.; Menning, A.; Eberth, G.; Pilz, M.; Arnhold, Ch.; Simon,; Adam, G.; Werner, C.
    Durable Surface Modification of Poly(tetrafluoroethylene) by Low Pressure H2O Plasma Treatment Followed by Acrylic Acid Graft Polymerization more
    Colloids and Surfaces B: Biointerfaces 24 (2002) 63-71

  26. Nitschke, M.; Schmack, G.; Janke, A.; Simon, F.; Pleul, D.; Werner, C.
    Low pressure plasma treatment of poly(3-hydroxybutyrate): Towards tailored polymer surfaces for tissue engineering scaffolds more
    Journal of Biomedical Materials Research 59 (2002) 632-638

  27. Lappan, U.; Nitschke, M.; Pleul, D.; Simon, F.; Uhlmann, St.
    Polyelectrolyte Adsorption on NH3-Plasma-Treated Poly(tetrafluoroethylene-co-hexafluoropropylene) more
    Plasmas and Polymers 6 (2001) 211-220

  28. Tusek, L.; Nitschke, M.; Werner, C.; Stana-Kleinschek, K.; Ribitsch, V.
    Surface characterization of NH3 plasma treated polyamide 6 foils more
    Colloids and Surfaces A: Physicochemical and Engineering Aspects 195 (2001) 81-95

  29. Nitschke, M.; Menning, A.; Werner, C.
    Immobilization of PEO-PPO-PEO triblock copolymers on PTFE-like fluorocarbon surfaces more
    Journal of Biomedical Materials Research 50 (2000) 340-343

Plasma Surface Functionalization
Plasma Surface Functionalization


Institute of Biofunctional Polymer Materials

Matrix Engineering

Plasma Surface Functionalization