Dr. Uwe Freudenberg

Dr. Uwe Freudenberg

Dr. Uwe Freudenberg
Biofunctional Polymer Materials
Tel. +49 (0)351 4658 408 / 573 / Fax +49 (0)351 4658 533

Personal data

  • 2001-2003: Process Engineer, AMD Saxony Manufacturing LLC & CoKG
  • since 2003: research scientist at the Leibniz Institute of Polymer Research Dresden
  • 2007: PhD at the faculty of Mechanical Engineering of the Technical University of Dresden

Fields of work

  • synthetic and biohybrid matrices for in vivo tissue engineering applications (injectable, functionalized gels)
  • cellulose thin films
  • charge formation processes at polymer interfaces


  1. Zieris, A.; Dockhorn, R.; Röhrich, A.; Zimmermann, R.; Müller, M.; Welzel, P.; Tsurkan, M.; Sommer, J.-U.; Freudenberg, U.; Werner, C.
    Biohybrid networks of selectively desulfated glycosaminoglycans for tunable growth factor delivery mehr
    Biomacromolecules 15 (2014) 4439-446

  2. Tsurkan, M.; Wetzel, R.; Pérez-Hernández, H.; Chwalek, K.; Kozlova, A.; Freudenberg, U.; Kempermann, G.; Zhang, Y.; Lasagni, A.; Werner, C.
    Photopatterning of multifunctional hydrogels to direct adult neural precursor cells mehr
    Advanced Healthcare Materials (2014) Early view

  3. Tsurkan, M.; Chwalek, K.; Schoder, M.; Freudenberg, U.; Werner, C.
    Chemoselective peptide functionalization of starPEG-GAG hydrogels mehr
    Bioconjugate Chemistry 25 (2014) 1942–1950

  4. Welzel, P.; Friedrichs, J.; Grimmer, M.; Vogler, S.; Freudenberg, U.; Werner, C.
    Cryogel micromechanics unraveled by atomic force microscopy-based nanoindentation mehr
    Advanced Healthcare Materials 3 (2014) 1849-1853

  5. Chwalek, K.; Tsurkan, M.; Freudenberg, U.; Werner, C.
    Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models mehr
    Scientific Reports 4 (2014) Article number: 4414

  6. Joly, P.; Duda, G. N.; Schöne, M.; Welzel, P.; Freudenberg, U.; Werner, C.; Petersen, A.
    Geometry-driven cell organization determines tissue growths in scaffold pores: Consequences for fibronectin organization mehr
    PLoS ONE 8 (2013) e73545

  7. Maitz, M.F.; Freudenberg, U.; Tsurkan, M.; Fischer, M.; Beyrich, T.; Werner, C.
    Bio-responsive polymer hydrogels homeostatically regulate blood coagulation mehr
    Nature Communications 4 (2013) 7 Seiten [OPEN]

  8. Krüger, K.; Terne, C.; Werner, C.; Freudenberg, U.; Jankowski, V.; Zidek, W.; Jankowski, J.
    Characterization of polymer membranes by MALDI-mass-spectrometric imaging techniques mehr
    Analytical Chemistry 85 (2013) S, 4998-5004

  9. Tsurkan, M.; Chwalek, K.; Prokoph, S.; Zieris, A.; Levental, K.; Freudenberg, U.; Werner, C.
    Defined polymer-peptide conjugates to form cell-instructive star PEG-heparin matrices in situ mehr
    Advanced Materials 25 (2013) 2606-2610

  10. Tsurkan, M.; Hauser, P. V.; Zieris, A.; Carvalhosa, R.; Bussolati, B.; Freudenberg, U.; Gamussi, G.; Werner, C.
    Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury mehr
    Journal of Controlled Release 167 (2013) 248-255

  11. Wieduwild, R.; Tsurkan, M.; Chwalek, K.; Murawala, P.; Nowak, M.; Freudenberg, U.; Neinhuis, C.; Werner, C.; Zhang, Y.
    Minimal peptide motif for non-covalent peptide-heparin hydrogels mehr
    Journal of the American Chemical Society 135 (2013) 2919-2922

  12. Zieris, A.; Werner, C.; Prokoph, S.; Levental, K.; Welzel, P.; Chwalek, K.; Schneider, K.; Freudenberg, U.
    Sustainable growth factor delivery through affinity-based adsorption to star PEG-heparin hydrogels mehr
    in: Proteins at Interfaces III State of the Art, Horbett, T. ; Brash, J.L. ; Norde, W., ed. (American Chemical Society 2012) 1120, Chapter 24, 525-541

  13. Zimmermann, R.; Bartsch, S.; Freudenberg, U.; Werner, C.
    Electrokinetic analysis to reveal composition and structure of biohybrid hydrogels mehr
    Analytical Chemistry 84 (2012) 9592-9595

  14. Welzel, P.; Grimmer, M.; Renneberg, C.; Naujox, L.; Zschoche, St.; Freudenberg, U.; Werner, C.
    Macroporous starPEG-heparin cryogels mehr
    Biomacromolecules 13 (2012) 2349-2358

  15. Baumann, L.; Prokoph, S.; Gabriel, C.; Freudenberg, U.; Werner, C.; Beck-Sickinger, A. G.
    A novel, biased-like SDF-1 derivative acts synergistically with star PEG -based heparin hydrogels and improves eEPC migration in vitro mehr
    Journal of Controlled Release 162 (2012) 68–75

  16. Prokoph, S.; Chavakis, E.; Levental, K.; Zieris, A.; Freudenberg, U.; Dimmeler, S.; Werner, C.
    Sustained delivery of SDF-1a from heparin-based hydrogels to attract circulating pro-angiogenic cells mehr
    Biomaterials 33 (2012) 4792-4800

  17. Freudenberg, U.; Sommer, J.-U.; Levental, K.; Welzel, P; Zieris, A.; Chwalek, K.; Schneider, K.; Prokoph, S.; Prewitz, M.; Dockhorn, R.; Werner, C.
    Using Mean Field Theory to Guide Biofunctional Materials Design mehr
    Advanced Functional Materials 22 (2012) 1391-1398

  18. Chwalek, K.; Levental, K.; Tsurkan, M.; Zieris, A.; Freudenberg, U.; Werner, C.
    Two-tier hydrogel degradation to boost endothelial cell morphogenesis mehr
    Biomaterials 32 (2011) 9649-9657

  19. Zieris, A.; Chwalek, K.; Prokoph, S.; Levental, K.; Welzel, P.; Freudenberg, U.; Werner, C.
    Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels mehr
    Journal of Controlled Release 156 (2011) 28-36

  20. Welzel, P.; Prokoph, S.; Zieris, A.; Grimmer, M.; Zschoche, St.; Freudenberg, U.; Werner, C.
    Modulating biofunctional starPEG heparin hydrogels by varying size and ratio of the constituents mehr
    Polymers [Open Access] 3 (2011) 602-620

  21. Sommer, J.-U.; Dockhorn, R.; Welzel, P.; Freudenberg, U.; Werner, C.
    Swelling equilibrium of a binary polymer gel mehr
    Macromolecules 44 (2011) 981–986

  22. Zieris, A.; Prokoph, S.; Levental, K.; Welzel, P.; Grimmer, M.; Freudenberg, U.; Werner, C.
    FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis mehr
    Biomaterials 31 (2010) 7985-7994

  23. Tsurkan, M.; Chwalek, K.; Levental, K.; Freudenberg, U.; Werner, C.
    Modular starPEG-heparin gels with bifunctional peptide linkers mehr
    Macromolecular Rapid Communications 31 (2010) 1529-1533

  24. Müller, Y.; Tot, I.; Potthast, A.; Rosenau, T.; Zimmermann, R.; Eichhorn, K.-J.; Nitschke, C.; Scherr, G.; Freudenberg, U.; Werner, C.
    The impact of esterification reactions on physical properties of cellulose thin films mehr
    Soft Matter 6 (2010) 3680-3684

  25. Zimmermann, R.; Freudenberg, U.; Schweiß, R.; Küttner, D.; Werner, C.
    Hydroxide and hydronium ion adsorption - A survey mehr
    Current Opinion in Colloid and Interface Science 15 (2010) 196-202

  26. Zieris, A.; Prokoph, S.; Welzel, P.; Grimmer, M.; Levental, K.; Panyanuwat, W.; Freudenberg, U.; Werner, C.
    Analytical approaches to uptake and release of hydrogel-associated FGF-2 mehr
    Journal of Materials Science : Materials in Medicine 21 (2010) 915-923

  27. Tsurkan, M.; Levental, K.; Freudenberg, U.; Werner, C.
    Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties mehr
    Chemical Communications 46 (2010) 1141-1143

  28. Lanfer, B.; Hermann, A.; Kirsch, M.; Freudenberg, U.; Reuner, U.; Werner, C.; Storch, A.
    Directed growth of adult human white matter stem cell-derived neurons on aligned fibrillar collagen mehr
    Tissue Engineering A 16 (2010) 1103-1113

  29. Grombe, R.; Gouzy, M.-F.; Freudenberg, U.; Pompe, T.; Zschoche, St.; Simon, F.; Eichhorn, K.-J.; Janke, A.; Voit, B.; Werner, C.
    Sulfated cellulose thin films with antithrombin affinity mehr
    eXPRESS Polymer Letters 3 (2009) 733-742

  30. Welzel, P.; Nitschke, M.; Freudenberg, U.; Zieris, A.; Götze, T.; Valtink, M.; Engelmann, K.; Werner, C. :
    Polymer Hydrogels to Enable New Medical Therapies mehr
    in: Hydrogel Sensors and Actuators : Engineering and Technology, Gerlach, G.; Arndt, K.-F., ed. (Springer 2009) 6, 249-266

  31. Lanfer, B.; Seib, P.; Freudenberg, U.; Stamov, D.; Bley, Th.; Bornhäuser, M.; Werner, C.
    The growth and differentiation of mesemchymal stem and progenitor cells cultured on aligned collagen matrices mehr
    Biomaterials 30 (2009) 5950-5958

  32. Freudenberg, U.; Hermann, A.; Welzel, P.; Stirl, K.; Schwarz, S.; Grimmer, M.; Zieris, A.; Panyanuwat, W.; Zschoche, St.; Meinhold, D.; Storch, A.; Werner, C.
    A starPEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases mehr
    Biomaterials 30 (2009) 5049-5060

  33. Lanfer, B.; Freudenberg, U.; Zimmermann, R.; Stamov, D.; Körber, V.; Werner, C.
    Aligned fibrillar collagen matrices obtained by shear flow deposition mehr
    Biomaterials 29 (2008) 3888-3895

  34. Freudenberg, U.; Zimmermann, R.; Schmidt, K.; Behrens, S.-H.; Werner, C.
    Charging and swelling of cellulose films mehr
    Journal of Colloid and Interface Science 309 (2007) 360-365

  35. Freudenberg, U.; Behrens, S.-H.; Welzel, P.; Müller, M.; Grimmer, M.; Salchert, K.; Taeger, T.; Schmidt, K.; Pompe, W.; Werner, C.
    Electrostatic interactions modulate the conformation of collagen I mehr
    Biophysical Journal 92 (2007) 2108-2119

  36. Grombe, R.; Gouzy, M.-F.; Maitz, M.F.; Freudenberg, U.; Zschoche, St.; Simon, F.; Pompe, T.; Sperling, C.; Werner, C.
    Sulfated glycopolymer thin films - preparation, characterization, and biological activity mehr
    Macromolecular Bioscience 7 (2007) 195-200

  37. Freudenberg, U.; Zschoche, St.; Simon,; Janke, A.; Schmidt, K.; Behrens, S.-H.; Auweter, H.; Werner, C.
    Covalent Immobilization of Cellulose Layers onto Maleic Anhydride Copolymer Thin Films mehr
    Biomacromolecules 6 (2005) 1628-1634

Dr. Uwe Freudenberg
Dr. Uwe Freudenberg


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Dr. Uwe Freudenberg