Mission
Synthetic and naturally derived polymer matrices are utilized to analyze and control cell fate decisions in dependence on microenvironmental cues. In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of growth factor presentation. Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous signalling in cells, the development of new biotechnological strategies, and regenerative therapies.
Group Members
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Grants
- Culture of Mesenchymal Stem Cells on BMP-Containing Bio-Artifical Matrices to Generate Interactive Niches for Early Hematopoietic Stem Cells (DFG)
- Charakterisierung und Modellierung der Fibronektin-Fibrillogenese auf definierten Polymersubstraten (DFG)
- Haematosys - Systembiologie der Hämatopoiese und hämatopoietischer Neoplasien (BMBF)
- Regenerative potential of mesenchymal stem cells (BMBF)
- EXIST-Gründerstipendium: CellDesign (EU/BMWi)
- KidStem - Developing a Stem Cell Based Therapy to Replace Nephrons Lost Through Reflux Nephropathy (EU)
- Angioscaff - Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds inTissue Engineering (EU)
Selected Publications
- Pompe, T.; Glorius, S.; Bischoff, T.; Uhlmann, I.; Kaufmann, M.; Brenner, S.; Werner, C.
Dissecting the impact of matrix anchorage and elasticity in cell adhesion mehr
Biophysical Journal 97 (2009) 2154-2163 - Stamov, D.; Salchert, K.; Springer, A.; Werner, C.; Pompe, T.
Structural polymorphism of collagen type I - Heparin Cofibrils mehr
Soft Matter 5 (2009) 3461-3468 - Kurth, I.; Franke, K.; Pompe, T.; Bornhäuser, M.; Werner, C.
Hematopoietic stem and progenitor cells in adhesive microcavities mehr
Integrative Biology 1 (2009) 427-434 - Herklotz, M.; Werner, C.; Pompe, T.
The impact of primary and secondary ligand coupling on extracellular matrix characteristics and formation of endothelial capillaries mehr
Biomaterials 30 (2009) 35-44 - Lanfer, B.; Freudenberg, U.; Zimmermann, R.; Stamov, D.; Körber, V.; Werner, C.
Aligned fibrillar collagen matrices obtained by shear flow deposition mehr
Biomaterials 29 (2008) 3888-3895 - Alberti, K.; Davey, R.; Onishi, K.; George, S.; Salchert, K.; Seib, P.; Bornhäuser, M.; Pompe, T.; Nagy, A.; Werner, C.; Zandstra, P. W.
Functional immobilization of signaling proteins enables control of stem cell fate mehr
Nature Methods 5 (2008) 645-650 - Renner, L.; Osaki, T.; Chiantia, S.; Schwille, P.; Pompe, T.; Werner, C.
Supported lipid bilayers on spacious and pH responsive polymer cushions with varied hydrophilicity mehr
Journal of Physical Chemistry / B 112 (2008) 6373-6378 - Pompe, T.; Starruss, J.; Bobeth, M.; Pompe, W.
Modeling of pattern development during fibronectin nanofibril formation mehr
Biointerphases 1 (2006) 93-97 - Pompe, T.; Renner, L.; Grimmer, M.; Herold, N.; Werner, C.
Functional Films of Maleic Anhydride Copolymers under Physiological Conditions mehr
Macromolecular Bioscience 5 (2005) 890-895 - Pompe, T.; Renner, L.; Werner, C.
Nanoscale Features of Fibronectin Fibrillogenesis Depend on Protein-Substrate Interaction and Cytoskeleton Structure mehr
Biophysical Journal 88 (2005) 527-534 - Renner, L.; Pompe, T.; Salchert, K.; Werner, C.
Dynamic Alterations of Fibronectin Layers on Copolymer Substrates with Graded Physiochemical Characteristics mehr
Langmuir 20 (2004) 2928-2933 - Pompe, T.; Zschoche, St.; Herold, N.; Salchert, K.; Gouzy, M.-F.; Sperling, C.; Werner, C.
Maleic Anhydride Copolymers - A Versatile Platform for Molecular Biosurface Engineering mehr
Biomacromolecules 4 (2003) 1072-1079
