Biomimetic molecules based on heparin

Heparin

  • Polysaccharide with high degree of sulfatation
  • Biomolecule with high negative charge density
  • Catalyzes the antithrombin dependent inhibition of thrombin and other coagulation factors.
  • No anticoagulant activity against fibrin bound thrombin
  • Surface adsorbed heparin loses activity.
  • Biodegradation of long chain heparins
  • Risk of life threatening heparin induced thrombocytopenia

It is expected that sulphated synthetic sugars are better stable at production and biostable in vivo and take the function of heparin. Mono- and disaccharides were sulphated and immobilized to surfaces. In addition the polysaccharide cellulose has been sulphated and immobilized.

The immobilized sulphated saccharides showed interaction with antithrombin with the affinity increasing with the chain length. The affinity of low- or high molecular weight heparin (LMW/HMW) for antithrombin was not reached.

References

  • Grombe R, Gouzy MF, Maitz MF, Freudenberg U, Zschoche S, Simon F, Pompe T, Sperling C, Werner C. Sulfated glycopolymer thin films - preparation, characterization and biological activity. Macromol Biosci 2007;7:195-200
  • Sperling C, Houska M, Brynda E, Streller U, Werner C. In vitro hemocompatibility of albumin-heparin multilayer coatings on polyethersulfone prepared by the layer-by-layer technique. Journal of Biomedical Materials Research 2006;A76:681-689
 
Biomimetic molecules based on heparin
Biomimetic molecules based on heparin
 

Departments

Institute of Biofunctional Polymer Materials

Fields of Work

Hemocompatible Interfaces

Anticoagulant Coatings